Our clinical development programs encompass both an autologous neuron replacement therapy in sporadic Parkinson’s disease (ANPD001) and a gene-corrected autologous neuron replacement therapy for genetic variants that increase the risk of Parkinson’s disease (ANPD002).
Our lead product (ANPD001) is currently undergoing investigational new drug (IND)-enabling studies for the treatment of sporadic Parkinson’s disease.
We are also working to develop a gene-corrected autologous neuron therapy (ANPD002) that is in the research stage and targeted towards genetic variants associated with a higher risk of developing Parkinson’s disease beginning with the most common genetic variant in the gene encoding glucocerebrosidase (GBA).
- Verstraeten A, Theuns J, Van Broeckhoven C. Progress in unraveling the genetic etiology of Parkinson’s disease in a genomic era. Trends Genet. (2015) 31:140–9. 10.1016/j.tig.2015.01.004
- Sidransky, Ellen, et al. “Multicenter analysis of glucocerebrosidase mutations in Parkinson’s disease.” New England Journal of Medicine 361.17 (2009): 1651-1661